Antimicrobial resistance could become the leading cause of death in the world, with 10 million deaths in 2050, if nothing is done to prevent it. Today, 400,000 people die each year because of antibiotic resistance. The Institut Pasteur has made the study of bacterial resistance and the fight against resistant bacteria one of its priorities. On the occasion of Pasteurdon 2020 (the Institut Pasteur’s public fundraising campaign), Mathieu Vidard interviews two Pasteurian researchers, Paola Arimondo and Philippe Glaser, who both coordinate this line of research.