The Institut Pasteur and the Institut Pasteur International Network are assisting the international aid effort by offering diagnostic support and epidemiological surveillance in collaboration with the Guinean Ministry of Health. On the occasion of the international congress " Targeting Ebola 2015 ", held at the Institut Pasteur in Paris on May 28 and 29, 2015, find all the information about research projects involving the Institute in the fight against Ebola.

L’Institut Pasteur et le Réseau International des Instituts Pasteur offrent leur assistance au plan d’aide international en matière d’appui au diagnostic et de surveillance épidémiologique, mis en œuvre en collaboration avec le ministère de la santé guinéen. A l'occasion de la conférence internationale "Targeting Ebola 2015", qui a lieu à l’Institut Pasteur à Paris, les 28 et 29 mai 2015, retrouvez tous les projets de recherche impliquant l'Institut dans la lutte contre Ebola.

En étudiant conjointement les interactions entre tous les individus présents dans un établissement hospitalier, l’expérimentation i-Bird a permis de mieux cerner les facteurs de propagation et de transmission des bactéries responsables d’infections nosocomiales. Des résultats qui tendent à confirmer l’utilité des nouvelles technologies dans l’analyse des épidémies.

Most of the viral pathogenic agents that have emerged in humans in recent decades are of animal origin. Hence, researchers from the Institut Pasteur have recently proved, for the first time scientifically at the epidemiological level, that specific contact with a monkey is a risk factor for the transmission of a pathogenic retrovirus (STLV-1/HTLV-1) to humans

Scientists have discovered how some of these restriction factors inhibit HIV replication in lymphocytes. These proteins belong to the IFITM (interferon-induced transmembrane proteins) family; they are broad-spectrum antiviral proteins that act on a wide range of viruses including influenza, dengue, etc. Little was previously known about their effect on HIV-1.

Scientists have demonstrated that liver-resident macrophages are rapidly killed by the pathogenic bacterium Listeria monocytogenes. This early death triggers the recruitment of macrophages from the bloodstream to the liver. These macrophages start by bringing the bacterial infection under control; then, in an unexpected development, they actually replace the liver-resident macrophages that have been killed by the infection.

Despite the vital role of segmented filamentous bacteria in establishing gut immune homeostasis in vivo in mice, scientists, for the past 50 years, have been unable to reproduce this symbiosis in vitro to shed light on the cellular and molecular interactions involved. Now, scientists have successfully cultured and reproduced the complex life-cycle of these bacteria outside their host for the first time.

Arnaud Echard (head of the Membrane Traffic and Cell Division Lab) and his team are working to understand how a parent cell physically "cleaves" itself in two to create two distinct daughter cells. The researchers revealed that intercellular bridges split and in doing so release a structure called "midbody remnant" (MBR) into the extracellular environment. This discovery could have a significant impact on cancer research, as the presence of MBR is thought to promote the uncontrolled production of tumor cells.

Researchers from the Institut Pasteur de Montevideo, in collaboration with the Uruguayan Medical School, obtained for the first time ever high-resolution images of the native capsid protein of the Bovine Leukemia Virus (BLV). These observations represent a major progress in understanding retrovirus biology, opening new avenues towards the development of antiretroviral therapies.

Les chercheurs de l’Institut Pasteur de Montevideo, en collaboration avec la faculté de médecine de l’Uruguay, ont obtenu, pour la première fois, des images haute résolution de la protéine non-modifiée de capside du virus de la leucémie bovine (VLB).  Ces observations représentent une avancée majeure dans la compréhension de la biologie des rétrovirus, ouvrant de nouvelles voies vers le développement de traitements antirétroviraux.