SODA, a new analysis tool for fluorescence imaging

SODA (Statistical Object Distance Analysis) is a new method for performing automatic statistical analysis on images and determining the spatial distribution of molecules. It has been made available free of charge for the scientific community via Icy and does not require any programming knowledge. This software is applicable to all fluorescence imaging and can be used for either conventional imaging or super-resolution imaging (SIM, STED or STORM).

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Just the two of us: Holding hands can ease pain, sync brainwaves

Reach for the hand of a loved one in pain and not only will your breathing and heart rate synchronize with theirs, your brain wave patterns will couple up too, according to a new study. The study, by researchers with CU Boulder and University of Haifa, in collaboration with the Institut Pasteur published in the journal Proceedings of the National Academy of Sciences (PNAS) this week, also found that the more empathy a comforting partner feels for a partner in pain, the more their brainwaves fall into sync.

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SODA, un nouvel outil d’analyse pour l'imagerie à fluorescence

SODA (Statistical Object Distance Analysis) est une nouvelle méthode qui permet de faire automatiquement l'analyse statistique d'images et de déterminer la distribution spatiale de molécules. Il est mis gratuitement à la disposition de la communauté scientifique sur Icy et peut s’utiliser sans connaissance de programmation. Ce logiciel concerne toute l'imagerie à fluorescence, et peut être utilisé soit pour l’imagerie conventionnelle soit pour l’imagerie de super-résolution (SIM, STED ou STORM).

French

Catherine Rougeot and the discovery of a new painkiller molecule

Catherine Rougeot, an Institut Pasteur guest researcher, was recognized by the Institut Pasteur in 2017 for her work in discovering a non-opioid analgesic, today called STR-324. She was appointed member of the National Academy of Inventors in the US on receiving this award. As the Institut Pasteur is celebrating its 130th anniversary this year – November 14, 2018 – let's look back at the discovery of this molecule, which is entering phase I clinical trials this month.

 

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New insight into body's response to killer fungus

Scientists at the University of Aberdeen, with colleagues from several institutions, including the Institut Pasteur, have made a new discovery that could help in the fight against a fungus that kills around 200,000 people every year and causes lung and allergic diseases in millions of others.

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Un nouvel éclairage sur la réponse de l’organisme à un champignon mortel

Les chercheurs de l’université d’Aberdeen, avec des confrères de plusieurs institutions dont l'Institut Pasteur, sont à l’origine d’une découverte susceptible de faire progresser la lutte contre un champignon qui tue chaque année près de 200 000 personnes et provoque des maladies pulmonaires et allergiques chez des millions d’autres.

French

Quand se tenir la main soulage la douleur par synchronisation des ondes cérébrales

Selon une nouvelle étude, prendre la main de son compagnon qui souffre permet non seulement de synchroniser sa respiration et son rythme cardiaque sur les siens, mais également d’accorder ses ondes cérébrales.

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Catherine Rougeot et la découverte d’une nouvelle molécule antidouleur

Catherine Rougeot, chercheur invité de l'Institut Pasteur, a été récompensée en 2017 par l’Institut Pasteur pour son travail sur la découverte d’un analgésique non opioïde, aujourd’hui appelé STR-324. Elle a été nommée membre de la National Academy of Inventors aux Etats-Unis à l’occasion de cette récompense. Alors que l’Institut Pasteur fête les 130 ans de son inauguration cette année – le 14 novembre 2018 – revenons sur la découverte de cette molécule qui entre, ce mois-ci, dans un essai clinique de phase I.

 

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Multiscale structure of the Escherichia coli genome

The Escherichia coli bacterium is a major focus of research in biology. But the higher-order organization of its genome had yet to be investigated using techniques such as chromosome conformation capture (3C/Hi-C). In a paper published in the journal Cell, scientists from the Institut Pasteur revealed using this approach the existence of several levels of chromosomal folding linked to known proteins, including condensin and the histon-like HU protein, whose roles in maintaining the structure of this genome were until now unclear.

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Staphylococcus aureus: a new mechanism involved in virulence and antibiotic resistance

An Institut Pasteur-CNRS research team has characterized a Staphylococcus aureus gene involved in virulence, biofilm formation and resistance to certain antibiotics. These results open up new avenues for understanding the control of S. aureus virulence mechanisms. This work was recently published in the journal PLoS Pathogens.

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