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News | 2015.07.29
A MOOC in vaccinology
A new MOOC developed by the Institut Pasteur will be launched on September 17, 2015. Thirty-one internationally renowned medicine professors, scientists, and public health professionals from many countries, will give a large overview of vaccinology: history, definitions, basic immunology, epidemiology, preclinical and clinical development, recent vaccines, and future challenges. This MOOC is...
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News | 2015.09.06
World Sepsis Day: fighting deadly infections
On September 11, the Institut Pasteur will host a conference for World Sepsis Day (WSD). Sepsis is a condition triggered by a serious infection (usually bacterial but occasionally fungal, viral or parasitic) that attacks the body's vital functions. Despite modern medical advances in vaccinations, antibiotics and intensive care, there is still a high death rate among sepsis victims. Septicemia...
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News | 2014.11.23
The Total Corporate Foundation and the Institut Pasteur launch a call for proposal on child health in resource limited countries
The Total Foundation Total and the Institut Pasteur has launched today a new call for proposal open until the 25th of next January as part of their long-lasting partnership. Specifically dedicated to the study of vaccine and/or therapeutic responses in children, this new call will support international research projects led by scientists belonging to the Institut Pasteur International...
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News | 2017.07.19
Pertussis : progress but lack of surveillance
Whooping cough is a highly contagious respiratory disease caused by the bacterium Bordetella pertussis, and which can be serious, or even fatal, for infants. Using a mathematical model, scientists from Honk Kong University and WHO have just published new estimates of the global weight of the disease. These new estimates indicate that the number of pertussis cases among children under 5 years of...
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Report | 2017.07.24
AIDS: progress and fresh hope
Having claimed the lives of close to 40 million people (source: OMS 2017) since HIV was discovered in 1983, AIDS is indeed a global health catastrophe. Significant progress has nevertheless been made over the last few years, particularly in developed countries, with longer life expectancy for patients on triple therapy. But this treatment does not eliminate the virus and must be taken for life....
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Article | 2020.06.16
Working towards controlled detection of SARS-CoV-2 by the innate immune system
Aim: controlling the SARS-CoV-2 outbreak requires both scientific knowledge and antiviral drugs. RIG-I-like receptors in the cell cytoplasm play a major role in detecting infection with RNA viruses and in initiating and modulating antiviral immunity. The aim of the project is to study the RNA ligands in the SARS-CoV-2 virus that are detected by these receptors. The project will shed light on...
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Article | 2020.07.07
Modeling human SARS-CoV-2 infection in mice with human lung xenografts
To date there is no specific therapeutic treatment or vaccine for COVID-19 caused by the SARS-CoV-2 virus and relevant animal models that mimic human COVID-19 pathologies are lacking. We will generate two novel humanized mouse models: HuLung mice (human lung) and HIS-HuLung mice (and human immune system and human lung). Infection of HuLung and HIS-HuLung mice with SARS-CoV-2 will provide an in...
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Document de presse | 2023.06.06
Monkeypox: characterization of post-infectious immune response
In 2022-2023, an outbreak of monkeypox, now known as mpox (caused by the monkeypox virus or MPXV) led to 87,000 human cases in 170 countries[1]. Most cases were reported outside the usual areas in which the virus circulates. Since the outbreak began, surveillance of the virus has been stepped up in Europe, with nearly 5,000 cases being reported in France[2]. Scientists and clinicians from the...
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Report | 2024.03.12
COVID-19: which monoclonal antibodies should be used for vulnerable individuals?
Vaccination does not offer sufficient protection against severe forms of COVID-19 for people with a weakened immune system. For these individuals, monoclonal antibodies have long been the preferred therapeutic solution. But depending on the SARS-CoV-2 variant, the effectiveness of these treatments has fluctuated. Scientists have had to develop novel antibodies that are more effective while also...
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Article | 2018.01.30
A program concerning the Hand-Foot-And-Mouth disease in South East Asia
The infection called "hand, foot and mouth" (HFMD) is a viral disease that mainly affects children under 5 years. It is transmitted by direct contact between infected children and is characterized by fever, mouth sores and blisters on the hands, feet and buttocks. To date, there is no specific treatment for this disease. A global approach is being developed in Southeast Asia to define...