1. Report | 2021.02.22

   SARS-CoV-2, COVID-19 epidemic: the Institut Pasteur's response, scientific research and discoveries in 2020

   The Institut Pasteur is one of the world's leading centers for research on infectious diseases. This area is therefore one of the priority research areas of its 2019-2023 strategic plan. On January 27, 2020, a 'coronavirus task force' was set up to respond to the urgency of this health crisis, by studying the virus and the disease it causes - the task force was created at a time when the 11...

2. Document de presse | 2021.03.26

   COVID-19: analysis of the sensitivity of the UK (B.1.1.7) and South African (B.1.351) variants to SARS-CoV-2 neutralizing antibodies

   The B.1.1.7 and B.1.351 variants of SARS-CoV-2 were first detected in the UK and South Africa respectively, and have since spread to many other countries. Scientists from the Institut Pasteur joined forces with Orléans Regional Hospital, Tours University Hospital, Créteil Intercommunal Hospital, Strasbourg University Hospital and Georges Pompidou European Hospital to study the sensitivity of...

3. News | 2024.06.11

   Strengthening Multisectoral and Regional Cooperation to Mitigate Vector-Borne Diseases in the Mediterranean

   The interconnectedness of our world has brought about significant challenges in public health, particularly with the rise of infectious epidemics. Globalization, climate change, and rapid urbanization have created fertile ground for the emergence and spread of diseases, as starkly illustrated by the COVID-19 pandemic. Among these threats, vector-borne diseases transmitted by mosquitoes and ticks...

4. Article | 2020.06.22

   Nicotinic modulation of SARS-CoV-2 infection in the brain

   Aim: This project aims at experimentally testing the hypothesis that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.

5. Article | 2020.06.22

   Evaluation of clinical presentation and evolution of SARS -CoV-2 coronavirus infection in Senegal

   Aim: The overall objective of this study is to understand the main clinical, biological, virologic and immunological characteristics of Covid-19 cases detected in Senegal in order to inform the development and updating of health guidelines for cases management and reduce the potential impact of infection. A retrospective and prospective cohort study of Covid-19 confirmed cases will be...

6. Article | 2020.06.16

   Antibody profiling in recovering patients and development of a serological test for an epidemiological survey in individuals exposed to SARS-CoV-2

   Aim: to develop a test that can be used to carry out an initial survey on the prevalence of antibodies in individuals exposed to the SARS-CoV-2 coronavirus. The aim is to obtain a specific serological test that can be used for high-throughput testing for Covid-19 infection.

7. Article | 2020.06.22

   Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting

   Aim: Worldwide, the health care workers play an essential role in the clinical management of Covid-19 patients, but in Africa they are also at risk of infection given the level of control measures in hospital wards. This study aims to obtain an early understanding of key epidemiological characteristics in the risk of transmission in healthcare workers in different African countries of the...

8. Article | 2020.06.22

   Evaluation of SARS-CoV-2 infection spread in various populations groups in Cameroon

   Aim: The high case fatality ratio of Covid-19 compared to the flu is a global preoccupation. It could be related to non-reporting of mild and asymptomatic infection whose role in transmission is not completely clear if not diagnosed. It is therefore of paramount importance to quickly evaluate the true extent of the infection of SARS-CoV-2. We planned it in different population groups (close...

9. Article | 2020.06.22

   Neurological implications of SARS-COV-2 infection – a transversal study

   Aim: The infection of the nasal mucosa and the lungs by CoV-2 may spread to the CNS, including the brainstem, thereby playing a potential key role in the severe respiratory distress observed in COVID-19. Although several clinical observations support this hypothesis, the knowledge in this field is very limited. To fill this gap, we will investigate CoV-2 neuroinvasion in humans, animal...

10. Article | 2020.07.07

    Modeling human SARS-CoV-2 infection in mice with human lung xenografts

    To date there is no specific therapeutic treatment or vaccine for COVID-19 caused by the SARS-CoV-2 virus and relevant animal models that mimic human COVID-19 pathologies are lacking. We will generate two novel humanized mouse models: HuLung mice (human lung) and HIS-HuLung mice (and human immune system and human lung). Infection of HuLung and HIS-HuLung mice with SARS-CoV-2 will provide an in...

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