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Aim: Serology is an important complementary tool to real-time PCR for diagnosing SARS-CoV-2, allowing detection of past and current infections. A multiplex Luminex serological assay will be optimized in Paris and transferred to Dakar, Abidjan and Yaoundé where blood samples will be tested for antibodies to SARS-CoV-2 and seasonal coronaviruses. Mathematical models will classify infected individuals and estimate levels of population immunity.