Population genetics
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2021.05.31
Diphtheria is a severe infection caused in humans by toxigenic strains of Corynebacterium diphtheriae bacteria. If left untreated, it leads to death in 5 to 25...
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2021.06.01
The structure of DNA and chromosomes is a major focus of research, but still holds a number of mysteries. Scientists from the Institut Pasteur and the CNRS...
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2021.05.21
Dominant optic atrophy (DOA) is one of the most common forms of mitochondrial disease. It can be caused by genetic mutations in OPA1 resulting in mitochondrial...
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2020.08.04
Resistance to artemisinin, the main component of current antimalarial treatments recommended by WHO, is widespread in South-East Asia, but has not been...
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2021.02.22
The Lymphopoiesis Unit identified within the first cells that seed the thymus a unique population of lymphoid progenitors. These cells can generate lymphoid...
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2020.10.17
Ludovic Deriano’s Unit studied cells mutated for NHEJ, the canonical repair pathway for DNA double-strand break. The researchers showed that those transformed...
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2020.03.05
Cells in vivo organize into 3D structures that underlie the shape and mechanics of tissues, as well as their biological function. Researchers mapped how...
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2020.07.16
Triplet repeat expansions are responsible for more than two dozen neurological and developmental disorders. Shortening these repeats with endonucleases could...
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2020.03.27
Replicative DNA polymerases have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, their processivity is...
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2021.04.30
It remains unclear whether and how neural stem cells (NSCs) are maintained at long-term in the vertebrate brain. Combining intravital imaging, genetic tracing...